Concepedia

Survival Analysis of Cancer Risk Reduction Strategies for <i>BRCA1/2</i> Mutation Carriers

Allison W. Kurian, Bronislava M. Sigal, Sylvia K. Plevritis

Journal of Clinical Oncology · 2009 · 235 citations · 69 references

DOIFull text

Open access

Abstract

Although PM at age 25 plus PO at age 40 years maximizes survival probability, substituting mammography plus MRI screening for PM seems to offer comparable survival. These results may guide women with BRCA1/2 mutations in their choices between prophylactic surgery and breast screening.

References

69

Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women's Health Initiative Randomized Controlled Trial

JAMA · 2002 · 15.7K citations · Full text

Genetic Heterogeneity and Penetrance Analysis of the BRCA1 and BRCA2 Genes in Breast Cancer Families

Deborah Ford, Douglas F. Easton, Michael R. Stratton et al. · The American Journal of Human Genetics · 1998 · 3K citations · Full text

American Cancer Society Guidelines for Breast Screening with MRI as an Adjunct to Mammography

Debbie Saslow, C. Boetes, Wylie Burke et al. · CA A Cancer Journal for Clinicians · 2007 · 2.6K citations · Full text

Effect of Screening and Adjuvant Therapy on Mortality from Breast Cancer

Donald A. Berry, Kathleen A. Cronin, Sylvia K. Plevritis et al. · New England Journal of Medicine · 2005 · 2.5K citations · Full text

Breast and Ovarian Cancer Risks Due to Inherited Mutations in <i>BRCA1</i> and <i>BRCA2</i>

Mary‐Claire King, Joan H. Marks, Jessica B. Mandell · Science · 2003 · 2.2K citations