Concepedia

A prospective study of acute drug‐induced liver injury in patients suffering from non‐alcoholic fatty liver disease

Giovanni Tarantino, Paolo Conca, Vincenzo Basile, Antonio Gentile, Domênico Capone, Giuliano Polichetti, Emilio Leo

Hepatology Research · 2007 · 154 citations · 16 references

DOI

Abstract

NAFLD conveys a nearly fourfold increase of DILI risk in obese middle-aged patients. NAFLD, characterized by mitochondrial dysfunction, could predispose to drug-induced hepatotoxicity that probably shares the same pathophysiological mechanism.

References

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Human anti-endoplasmic reticulum autoantibodies appearing in a drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug.

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