Concepedia

Translationally Controlled Tumor Protein Induces Mitotic Defects and Chromosome Missegregation in Hepatocellular Carcinoma Development

Tim Hon Man Chan, Leilei Chen, Ming Liu, Liang Hu, Bo-Jian Zheng, Vincent Kwok‐Man Poon, Pinzhu Huang, Yunfei Yuan, Jian‐Dong Huang, Jie Yang,

Hepatology · 2011 · 79 citations · 28 references

DOI

Abstract

Collectively, we reveal a novel molecular pathway (CHD1L/TCTP/Cdc25C/Cdk1), which causes the malignant transformation of hepatocytes with the phenotypes of accelerated mitotic progression and the production of aneuploidy.

References

28

Global cancer statistics

Ahmedin Jemal, Freddie Bray · CA A Cancer Journal for Clinicians · 2011 · 55K citations · Full text

Global Cancer Statistics, 2002

Donald Maxwell Parkin, Freddie Bray, Jacques Ferlay et al. · CA A Cancer Journal for Clinicians · 2005 · 18.4K citations · Full text

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Matlnd and Matlnspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

Kerstin Quandt, Kornelie Frech, Holger Karas et al. · Nucleic Acids Research · 1995 · 2.6K citations

MatInspector and beyond: promoter analysis based on transcription factor binding sites

Kerstin Cartharius, Kornelie Frech, Korbinian Grote et al. · Computer applications in the biosciences · 2005 · 1.9K citations · Full text

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

Scott L. Carter, Aron C. Eklund, Isaac S. Kohane et al. · Nature Genetics · 2006 · 1.2K citations

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