Concepedia

Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples

Koji Yoshimoto, Julie Dang, Shaojun Zhu, David A. Nathanson, Tiffany Huang, Rebecca A. Dumont, David B. Seligson, William H. Yong, Zhenggang Xiong, Nagesh Rao,

Clinical Cancer Research · 2008 · 108 citations · 21 references

DOIFull text

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Abstract

This assay will facilitate accurate assessment of EGFRvIII in clinical samples and may aid in the development of strategies for stratifying patients for EGFRvIII-directed therapies.

References

21

Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors

Ingo K. Mellinghoff, Maria Y. Wang, Igor Vivanco et al. · New England Journal of Medicine · 2005 · 1.4K citations · Full text

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.

Ryo Nishikawa, Xiang-Dong Ji, R. Christopher Harmon et al. · Proceedings of the National Academy of Sciences · 1994 · 926 citations

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Structural alterations of the epidermal growth factor receptor gene in human gliomas.

Albert J. Wong, J. Michael Ruppert, Sandra H. Bigner et al. · Proceedings of the National Academy of Sciences · 1992 · 858 citations · Full text

, , +12

Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

Lori Frederick, Xiao Yang Wang, Greg Eley et al. · PubMed · 2000 · 669 citations

, , +14

PTEN Mutation, EGFR Amplification, and Outcome in Patients With Anaplastic Astrocytoma and Glioblastoma Multiforme

Justin S. Smith, Issei Tachibana, Sandra Passe et al. · JNCI Journal of the National Cancer Institute · 2001 · 642 citations