Perinatal Micronutrient Supplements Ameliorate Hypertension and Proteinuria in Adult Fawn-Hooded Hypertensive Rats

Abstract

In sum, perinatal micronutrients that enhance NO availability ameliorated development of hypertension and proteinuria in FHH rats. Antihypertensive effects were more pronounced in male FHH offspring, whereas renal protective effects were more pronounced in female FHH offspring. Mechanisms underlying gender-specific consequences of perinatal micronutrients require further study.