Antimicrobial Agents and Chemotherapy · 2006 · 112 citations · 8 references
Staphylococcus AureusMultidrug-resistant Nosocomial StrainsAntimicrobial ChemotherapyBacterial PathogensDrug ResistanceInfection ControlAntimicrobial ResistanceHealth SciencesAntibacterial AgentAntimicrobial CompoundPharmacologyClinical MicrobiologyVitro Bactericidal ActivityAntimicrobial SusceptibilityAntibioticsHuman Beta-defensin 3Antimicrobial ActivityMicrobiologyMedicineHuman β-Defensin 3
The antimicrobial activity of human beta-defensin 3 (hBD-3) against multidrug-resistant clinical isolates of Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter baumannii was evaluated. A fast bactericidal effect (within 20 min) against all bacterial strains tested was observed. The presence of 20% human serum abolished the bactericidal activity of hBD-3 against gram-negative strains and reduced the activity of the peptide against gram-positive strains.
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Giuseppantonio Maisetta, Giovanna Batoni, Semih Esin et al. · Antimicrobial Agents and Chemotherapy · 2003 · 88 citations · Full text
Bactericidal Activity, Bactericidal Effect, Antimicrobial Chemotherapy +18