Susceptibility of <i>Streptococcus</i> <i>mutans</i> and <i>Actinobacillus</i> <i>actinomycetemcomitans</i> to Bactericidal Activity of Human β-Defensin 3 in Biological Fluids - Concepedia

Concepedia

Publication | Open Access

Susceptibility of <i>Streptococcus</i> <i>mutans</i> and <i>Actinobacillus</i> <i>actinomycetemcomitans</i> to Bactericidal Activity of Human β-Defensin 3 in Biological Fluids

DOI Full Paper Access

29

Citations

8

References

2005

Year

Giuseppantonio Maisetta, Giovanna Batoni, Semih Esin, Giorgio Raco, Daria Bottai, Flavia Favilli, Walter Florio, Mario Campa

Antimicrobial Agents and Chemotherapy

Biological FluidsFast Bactericidal EffectPathogenic MicrobiologyMicrobial PathogensBactericidal ActivityBacteriologyBacterial PathogensDrug ResistanceMedical MicrobiologyInfection ControlAntimicrobial ResistanceHealth SciencesAntibacterial AgentAntimicrobial CompoundPharmacologyClinical MicrobiologyOral InfectionsAntimicrobial SusceptibilityMicrobial DiseaseAntibioticsHuman Beta-defensin 3MicrobiologyMedicineHuman β-Defensin 3

Abstract

Bactericidal activity of human beta-defensin 3 (hBD-3) against Streptococcus mutans and Actinobacillus actinomycetemcomitans was inhibited in a dose-dependent manner by the presence of saliva and/or serum. Increasing the concentration of hBD-3 partially overcame this inhibition. A fast bactericidal effect was observed against both bacterial strains, suggesting a potential therapeutic use for hBD-3 in the local treatment of oral infections.

References

	Year	Citations

Page 1