Organic & Biomolecular Chemistry · 2012 · 24 citations · 49 references
EngineeringDiversity-oriented SynthesisOrganic ChemistryConcurrent QuarternizationTertiary CarbamoylimidazoleGeneral MethodSynthesis MethodNatural Product SynthesisSynthetic ChemistryImidazole NitrogenBiomolecular Engineering
An efficient and general method for the synthesis of unsymmetrical tetrasubstituted ureas from carbamoylimidazole is described. The conversion is achieved by the concurrent quarternization of the imidazole nitrogen and activation of amines with AlMe(3).
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