Concepedia

<i>In Vivo</i>Quantification of Human Serotonin 1A Receptor Using<sup>11</sup>C-CUMI-101, an Agonist PET Radiotracer

Matthew S. Milak, Christine DeLorenzo, Francesca Zanderigo, Jaya Prabhakaran, J.S. Dileep Kumar, Vattoly J. Majo, J. John Mann, Ramin V. Parsey

Journal of Nuclear Medicine · 2010 · 82 citations · 32 references

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Abstract

On the basis of its measurable and stable free fraction, high affinity and selectivity, good blood-brain barrier permeability, and plasma and brain kinetics, (11)C-CUMI-101 is suitable for the imaging of high-affinity 5-HT(1A) binding in humans.

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