Concepedia

Detection of novel and potentially actionable anaplastic lymphoma kinase (<i>ALK</i>) rearrangement in colorectal adenocarcinoma by immunohistochemistry screening

Jeeyun Lee, Hee Cheol Kim, Jung Yong Hong, Kai Wang, Sun Young Kim, Jiryeon Jang, Seung Tae Kim, Joon Oh Park, Ho Yeong Lim, Won Ki Kang,

Oncotarget · 2015 · 37 citations · 20 references

DOIFull text

Open access

Abstract

ALK IHC is a viable screening strategy for identifying ALK rearrangement in CRC. ALK rearrangement is a potential actionable driver mutation in CRC based on survival inhibition of patient tumor-derived cell line by potent ALK inhibitors.

References

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