The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

Akihiko Iwai, Eliezer Masliah, Makoto Yoshimoto, +5

Neuron

Disease AmyloidSynaptic TransmissionMolecular BiologySynaptic SignalingNeurobiology Of Disease +15

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

Glenn C. Telling, Michael Scott, James A. Mastrianni, +5

Cell

Systems BiologyProtein ExpressionCellular PrpPrion DiseaseGene Expression +3

Fibrils Formed in Vitro from α-Synuclein and Two Mutant Forms Linked to Parkinson's Disease are Typical Amyloid

Kelly A. Conway, James D. Harper, Peter T. Lansbury

Biochemistry

Typical AmyloidMolecular BiologyMutant FormsSocial SciencesAlzheimer's Disease +14

Neuropathological Diagnostic Criteria for Creutzfeldt‐Jakob Disease (CJD) and Other Human Spongiform Encephalopathies (Prion Diseases)

Herbert Budka, Adriano Aguzzi, Paul Brown, +13

Brain Pathology

Chaperone-supervised conversion of prion protein to its protease-resistant form

Shubhik DebBurman, Gregory J. Raymond, Byron Caughey, +1

Proceedings of the National Academy of Sciences

Chaperone‐like activity of synucleins

José M. Souza, Benoit I. Giasson, Virginia M.‐Y. Lee, +1

FEBS Letters

Chaperone‐like ActivityMolecular BiologySynaptic SignalingProtein FoldingA30p Mutant α‐Synuclein +18

Overexpression of human α-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells

Wenbo Zhou, Marc Hurlbert, Jerome Schaack, +2

Brain Research

Cell DeathSynaptic SignalingSocial SciencesHuman α-Synuclein CausesExperimental Neuropathology +15

NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation.

Makoto Yoshimoto, Akihiko Iwai, David E. Kang, +3

Proceedings of the National Academy of Sciences

Molecular BiologyAlzheimer's DiseaseProtein FoldingDegenerative PathologyProtein Misfolding +15

Non-Aβ Component of Alzheimer's Disease Amyloid (NAC) Revisited

Janetta G. Culvenor, Catriona McLean, Sally Cutt, +7

American Journal Of Pathology

Neurodegenerative DiseasesAlzheimer's DiseaseDisease AmyloidProtein MisfoldingNeurology +4

Amyloid-like inclusions in Huntington’s disease

Daniel McGowan, Willeke van Roon‐Mom, Hilary Holloway, +5

Neuroscience

Neurodegenerative DiseasesDegenerative DiseaseProtein MisfoldingNeurologyNeuroscience +4