An increase in the <i>Akkermansia</i> spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

Abstract

Modulation of the gut microbiota (by an increase in the Akkermansia spp. population) may contribute to the antidiabetic effects of metformin, thereby providing a new mechanism for the therapeutic effect of metformin in patients with T2D. This suggests that pharmacological manipulation of the gut microbiota in favour of Akkermansia may be a potential treatment for T2D.