Both osteopontin‐c and osteopontin‐b splicing isoforms exert pro‐tumorigenic roles in prostate cancer cells

Tatiana Martins Tilli, Kivvi Duarte de Mello, Luciana Bueno Ferreira, Aline da Rocha Matos, Maria Thereza S. Accioly, Paulo Antônio Silvestre de Faria, Akeila Bellahcène, Vincent Castronovo, Etel Rodrigues Pereira Gimba

The Prostate · 2012 · 49 citations · 19 references

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Abstract

Our data provide evidence that both OPNc and OPNb splicing isoforms promote distinct aspects of PCa progression by inducing PI3K signaling. These data give support to strategies aiming to downregulate OPNc and OPNb expression as an approach to inhibit PCa progression.

References

19