Noncovalent Interactions in Organocatalysis: Modulating Conformational Diversity and Reactivity in the MacMillan Catalyst

Abstract

Intriguing imidazolidinones! Inspired by noncovalent interactions in proteins, a series of electronically distinct MacMillan catalysts were designed. The effect of electronic modulation on ground state conformation, reactivity, and performance was studied in a catalytic setting with intriguing outcomes.