Concepedia

Rituximab modifies the cisplatin-mitochondrial signaling pathway, resulting in apoptosis in cisplatin-resistant non-Hodgkin's lymphoma.

Steve Alas, Chuen‐Pei Ng, Benjamin Bonavida

PubMed · 2002 · 89 citations · 30 references

Abstract

These findings show that the selective down-regulation of Bcl-2 by rituximab leading to apoptosis in ARL cells by cisplatin is through the mitochondria-dependent caspase pathway.

References

30

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