Concepedia

Effectiveness of biologic DMARDs in monotherapy versus in combination with synthetic DMARDs in rheumatoid arthritis: data from the Swiss Clinical Quality Management Registry

Cem Gabay, Myriam Riek, Almut Scherer, Axel Finckh

Lara D. Veeken · 2015 · 94 citations · 25 references

DOI

Abstract

Our data suggest that bDMARD monotherapy is prescribed to more complex cases and is significantly less effective than bDMARD therapy in combination with sDMARDs, but to an extent that is clinically only marginally relevant.

References

25

Statistical Analysis With Missing Data

Maureen Lahiff, Roderick J. A. Little, Donald B. Rubin · Journal of the American Statistical Association · 1989 · 17.5K citations

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Efficacy of B-Cell–Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis

Jonathan Edwards, L Szczepański, Jacek Szechiński et al. · New England Journal of Medicine · 2004 · 2.6K citations · Full text

EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update

Josef S Smolen, Robert Landewé, Ferdinand C. Breedveld et al. · Annals of the Rheumatic Diseases · 2013 · 1.8K citations · Full text

Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

Graeme Jones, Anthony Sebba, Jianhui Gu et al. · Annals of the Rheumatic Diseases · 2009 · 789 citations · Full text

Multiple Imputation for Missing Data

Paul D. Allison · Sociological Methods & Research · 2000 · 789 citations

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