Brain Reserpine Levels Following Large and Small Doses of Reserpine-H3

Abstract

Summary(1) Reserpine randomly labeled with tritium had a time-concentration relationship in liver and brain similar to that observed for reserpine labeled with C14 in the TMBA moiety. (2) Throughout and beyond the entire period of observable pharmacological response, reserpine was found to be present in brain and liver. (3) The concentration of reserpine in the brain varied little during the entire period of observable activity and bore no relationship to the intensity of response. (4) The material present in the brain was indistinguishable from reserpine by paper chromatography.