JAMA · 1997 · 662 citations · 18 references
Sepsis syndrome is common in academic hospitals, although the overall rates vary considerably with the patient population. A substantial fraction of cases occur outside ICUs. An understanding of the hospitalwide epidemiology of sepsis syndrome is vital for rational planning and treatment of hospitalized patients with sepsis syndrome, especially as new and expensive therapeutic agents become available.
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The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)
M. Sigfrido Rangel‐Frausto, Didier Pittet, Michele Costigan et al. · JAMA · 1995 · 2K citations