Concepedia

Nucleophilic aromatic substitution using Et3SiH/cat. t-Bu-P4 as a system for nucleophile activation

Masahiro Ueno, Misato Yonemoto, Masahiro Hashimoto, Andrew E. H. Wheatley, Hiroshi Naka, Yoshinori Kondo

Chemical Communications · 2007 · 53 citations · 28 references

DOI

Abstract

A novel type of deprotonative arylation of nucleophiles was conducted using Et(3)SiH/cat. t-Bu-P4 and the powerful S(N)Ar reactions of aryl fluorides were accomplished using alcohols and malonates as nucleophiles.

References

28

Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones:  A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Flora Tang et al. · Journal of Medicinal Chemistry · 1998 · 486 citations · Full text

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Peralkylated Polyaminophosphazenes— Extremely Strong, Neutral Nitrogen Bases

Reinhard Schwesinger, Helmut Schlemper · Angewandte Chemie International Edition in English · 1987 · 408 citations

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Extremely Strong, Uncharged Auxiliary Bases; Monomeric and Polymer‐Supported Polyaminophosphazenes (P<sub>2</sub>–P<sub>5</sub>)

Reinhard Schwesinger, Helmut Schlemper, Christian Hasenfratz et al. · Liebigs Annalen · 1996 · 354 citations

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Design, Synthesis, and Evaluations of Substituted 3-[(3- or 4-Carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as Inhibitors of VEGF, FGF, and PDGF Receptor Tyrosine Kinases

Li Sun, Ngoc Quang Tran, Congxin Liang et al. · Journal of Medicinal Chemistry · 1999 · 271 citations · Full text

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Organocatalytic Regio- and Asymmetric <i>C</i>-Selective S<sub>N</sub>Ar ReactionsStereoselective Synthesis of Optically Active Spiro-pyrrolidone-3,3‘-oxoindoles

Marco Bella, Sara Kobbelgaard, Karl Anker Jørgensen · Journal of the American Chemical Society · 2005 · 186 citations

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