Concepedia

Acetyl L-Carnitine Slows Decline in Younger Patients With Alzheimer's Disease: A Reanalysis of a Double-Blind, Placebo-Controlled Study Using the Trilinear Approach

John O. Brooks, Jerome A. Yesavage, Angelico Carta, Daniele Bravi

International Psychogeriatrics · 1998 · 61 citations · 9 references

DOIFull text

Open access

Abstract

ALC slows the progression of Alzheimer's disease in younger subjects, and the use of the trilinear approach to estimate the average rate of change may prove valuable in pharmacological trials.

References

9

Clinical diagnosis of Alzheimer's disease

Guy M. McKhann, David A. Drachman, Marshall Folstein et al. · Neurology · 1984 · 27.8K citations · Full text

A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients With Alzheimer's Disease

Margaret J. Knapp · JAMA · 1994 · 974 citations

Long‐term acetyl‐L‐carnitine treatment in Alzheimer's disease

Alessandra Spagnoli, Ugo Lucca, G. Menasce et al. · Neurology · 1991 · 234 citations

, , +19

A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease

L. J. Thal, Angelico Carta, William R. Clarke et al. · Neurology · 1996 · 151 citations

Acetyl-l-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats

Assunta Impérato, M. T. Ramacci, Luciano Angelucci · Neuroscience Letters · 1989 · 87 citations

, , +10