Pathogenesis of Herpetic Stromal Keratitis in CCR5- and/or CXCR3-Deficient Mice

Abstract

The suppression of chemotaxis and activation of CD4+ Th1 cells by the lacking of CXCR3 and CCR5 causes a decrease of other infiltrating cells, resulting in a lower severity of HSK. These results suggest that targeting chemokine receptors is a promising way to treat HSK.