Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Anne Brunet, Azad Bonni, Michael J. Zigmond, +7

Cell

Systems BiologySignal TransductionCell RegulationForkhead Transcription FactorSignaling Pathway +8

Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study

Daniel Levy, Robert J. Garrison, Daniel D. Savage, +2

New England Journal of Medicine

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

Sue C. Bodine, Esther Latres, Susanne Baumhueter, +13

Science

Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

Marco Sandri, Claudia Sandri, Alex Gilbert, +7

Cell

Transcriptional RegulationSkeletal MuscleGeneticsMolecular GeneticsGene Expression +4

The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

Trevor N. Stitt, Doreen Drujan, Brian Clarke, +6

Molecular Cell

Muscle FunctionSignaling PathwayCell RegulationSkeletal MuscleMedicine +6

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

Marcelo D. Gomes, Stewart H. Lecker, R. Thomas Jagoe, +2

Proceedings of the National Academy of Sciences

Muscle FunctionMolecular PhysiologyProtein ExpressionProtein FunctionSkeletal Muscle +13

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

Stewart H. Lecker, R. Thomas Jagoe, Alexander D. Gilbert, +6

The FASEB Journal

Muscle FunctionGeneticsMuscle Atrophy ShareGene CharacterizationMolecular Genetics +19

Structure of the Cul1–Rbx1–Skp1–F boxSkp2 SCF ubiquitin ligase complex

Ning Zheng, Brenda A. Schulman, Langzhou Song, +11

Nature

Structural BiologyMolecular BiologyProtein X-ray Crystallography

SKP1 Connects Cell Cycle Regulators to the Ubiquitin Proteolysis Machinery through a Novel Motif, the F-Box

Chang Bai, Partha Sen, Kay Hofmann, +4

Cell

Protein FunctionCell RegulationCell DivisionMedicineNatural Sciences +9

Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice

Han Cho, Joanne L. Thorvaldsen, Qingwei Chu, +2

Journal of Biological Chemistry