Sustained Reduction in the Clinical Incidence of Methicillin-Resistant <i>Staphylococcus aureus</i> Colonization or Infection Associated with a Multifaceted Infection Control Intervention

Abstract

Sustained decreases in hospital-wide clinical incidence of MRSA colonization or infection, incidence of MRSA bloodstream infection, and proportion of S. aureus isolates resistant to methicillin followed implementation of a multifaceted prevention program at one Veterans Affairs hospital. Findings suggest that interventions designed to prevent transmission can impact endemic antimicrobial resistance problems.