Enantioselective Diels–Alder Reactions with G‐Quadruplex DNA‐Based Catalysts

Abstract

DNA in command: An enantioselective Diels–Alder reaction can be achieved using human telomeric G-quadruplex DNA-based catalysts. The absolute configuration of the product can be reversed when the conformation of G-quadruplex DNA is switched from antiparallel to parallel, and both the reaction rate and the enantioselectivity of the Diels–Alder reaction were found to be dependent on the DNA sequence.