Concepedia

Combinatorial Administration of Molecules That Simultaneously Inhibit Angiogenesis and Invasion Leads to Increased Therapeutic Efficacy in Mouse Models of Malignant Glioma

Lorenzo Bello, Valeria Lucini, Francesco Costa, Mauro Pluderi, Carlo Giussani, Francesco Acerbi, Giorgio Carrabba, Marilou Pannacci, Dario Caronzolo, Silvia Grosso,

Clinical Cancer Research · 2004 · 49 citations · 18 references

DOIFull text

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Abstract

This supports the concept that prolonged glioma growth inhibition can be achieved by simultaneous delivery of molecules that target both tumor and endothelial cells and acting by separate mechanisms.

References

18

Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

Selma Pennacchietti, Paolo Michieli, Massimiliano Mazzone et al. · Cancer Cell · 2003 · 1.3K citations · Full text

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Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

Peter C. Brooks, Steve Silletti, Tami L von Schalscha et al. · Cell · 1998 · 618 citations · Full text

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Microvessel density is a prognostic indicator for patients with astroglial brain tumors

Steven Leon, Rebecca D. Folkerth, Peter McL. Black · Cancer · 1996 · 487 citations · Full text

Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2.

Philip Kunkel, Ulrike Ulbricht, Peter Böhlen et al. · PubMed · 2001 · 401 citations

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Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398.

Tatsuhiro Joki, Oliver Heese, Demetrios C. Nikas et al. · PubMed · 2000 · 265 citations

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