Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

Selma Pennacchietti, Paolo Michieli, Massimiliano Mazzone, +2

Cancer Cell

Transcriptional RegulationDevelopmental BiologyInvasive GrowthRedox RegulatorHypoxia (Medicine) +6

Overexpression and activation of hepatocyte growth factor/scatter factor in human non-small-cell lung carcinomas

Martina Olivero, Marco Rizzo, Roberto Madeddu, +8

British Journal of Cancer

Liver PhysiologyPathologyBronchial NeoplasmMedicineCell Biology +4

Agonistic monoclonal antibodies against the Met receptor dissect the biological responses to HGF

María Prat, Tiziana Crepaldi, Selma Pennacchietti, +2

Journal of Cell Science

Human GrowthImmunologyPathologyMet ReceptorImmunotherapy +18

Tivantinib (ARQ197) Displays Cytotoxic Activity That Is Independent of Its Ability to Bind MET

Cristina Basilico, Selma Pennacchietti, Elisa Vigna, +6

Clinical Cancer Research

Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists

Paolo Michieli, Cristina Basilico, Selma Pennacchietti, +5

Oncogene

Mutant Met-mediated TransformationSignal TransductionSignaling PathwayReceptor Tyrosine KinaseMolecular Biology +6

An uncleavable form of pro–scatter factor suppresses tumor growth and dissemination in mice

Massimiliano Mazzone, Cristina Basilico, Silvia Cavassa, +5

Journal of Clinical Investigation

Uncleavable FormImmunologyCell ProliferationCancer BiologyTumor Biology +20

Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs

Selma Pennacchietti, Manuela Cazzanti, Andrea Bertotti, +7

Cancer Research

Chemoprevention StrategyMedicinePharmacologyCancer GrowthFibroblast Growth Factor +11

Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis

Selma Pennacchietti, Stefania Rosano, Paolo M. Comoglio, +1

Journal of Clinical Investigation

Inhibits MetastasisCancer BiologyRedox BiologyTumor BiologyHeme Trafficking +16

Negative Feedback Regulation of Met-Dependent Invasive Growth by Notch

Maria Cristina Stella, Livio Trusolino, Selma Pennacchietti, +1

Molecular and Cellular Biology

“Active” Cancer Immunotherapy by Anti-Met Antibody Gene Transfer

Elisa Vigna, Giovanni Pacchiana, Massimiliano Mazzone, +5

Cancer Research