Radiosynthesis, Photoisomerization, Biodistribution, and Metabolite Analysis of ¹¹C-PBB3 as a Clinically Useful PET Probe for Imaging of Tau Pathology

Abstract

(11)C-PBB3 was produced with sufficient radioactivity and high quality, demonstrating its clinical utility. The present results of radiosynthesis, photoisomerization, biodistribution, and metabolite analysis could be helpful for the reliable production and application of (11)C-PBB3 in diverse PET facilities.