Overproduction of VLDL ₁ Driven by Hyperglycemia Is a Dominant Feature of Diabetic Dyslipidemia

Abstract

Insulin resistance and DM2 are associated with excess hepatic production of VLDL1 particles similar in size and composition to those in nondiabetic subjects. We propose that hyperglycemia is the driving force that aggravates overproduction of VLDL1 in DM2.