Concepedia

Recombinant human lactoferrin inhibits matrix metalloproteinase (MMP‐2, MMP‐3, and MMP‐9) activity in a rabbit preterm delivery model

Ken Nakayama, Katsufumi Otsuki, Kyoko Yakuwa, Akitoshi Hasegawa, Maki Sawada, Kaori Mitsukawa, Hiroshi Chiba, Masaaki Nagatsuka, Takashi Okai

Journal of obstetrics and gynaecology research · 2008 · 16 citations · 20 references

DOI

Abstract

These results suggest that the prevention of preterm delivery by rh-LF in a rabbit model has been achieved through inhibition of cervical maturation promoted by matrix metalloproteinase activity.

References

20

Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-κB

Liliana Håversen, Bertil G. Ohlsson, Mirjana Hahn‐Zoric et al. · Cellular Immunology · 2002 · 330 citations

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Regulation of cytokine release from mononuclear cells by the iron- binding protein lactoferrin

S P Crouch, KJ Slater, John Fletcher · Blood · 1992 · 281 citations · Full text

Lactoferrin regulates the release of tumour necrosis factor alpha and interleukin 6 in vivo.

Michał Machnicki, Michał Zimecki, T. Zagulski · PubMed · 1993 · 232 citations

, , +19

Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin

Hungyi Shau, Anthony Kim, Sidney H. Golub · Journal of Leukocyte Biology · 1992 · 154 citations · Full text

, , +15

Increased concentration of pro–matrix metalloproteinase 9 in term fetal membranes overlying the cervix before labor: Implications for membrane remodeling and rupture

J. McLaren, David J. Taylor, S.C. Bell · American Journal of Obstetrics and Gynecology · 2000 · 137 citations

, , +15