Poxvirus Orthologous Clusters (POCs)

Abstract

Abstract Summary: Poxvirus Orthologous Clusters (POCs) is a JAVA client–server application which accesses an updated database containing all complete poxvirus genomes; it automatically groups orthologous genes into families based on BLASTP scores for assessment by a human database curator. POCs has a user-friendly interface permitting complex SQL queries to retrieve interesting groups of DNA and protein sequences as well as gene families for subsequent interrogation by a variety of integrated tools: BLASTP, BLASTX, TBLASTN, Jalview (multiple alignment), Dotlet (Dotplot), Laj (local alignment), and NAP (nucleotide to amino acid alignment). Availability: Direct access to the POCs database via the GENOME ANALYSIS link at the Poxvirus Bioinformatics Resource: http://www.poxvirus.org. The Software is available for download via HTTP at: http://athena.bioc.uvic.ca/pbr/POCs/pocs.html. Contact: cupton@uvic.ca Supplementary Information: Installation instructions, the User's Manual, screenshots, and examples are available at the POCs home page http://athena.bioc.uvic.ca/pbr/POCs/pocs.html. The software is free for non-commercial applications. For information on poxviruses see http://www.poxvirus.org. * To whom correspondence should be addressed.