Detection of early behavioral markers of Huntington's disease in R6/2 mice employing an automated social home cage

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Marcy E. MacDonald · Cell · 1993 · 8.4K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

Laura Mangiarini, Kirupa Sathasivam, Mary J. Seller et al. · Cell · 1996 · 3.1K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation

Rebecca J. Carter, Lisa A. Lione, Trevor Humby et al. · Journal of Neuroscience · 1999 · 959 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

Scott Zeitlin, Jeh-Ping Liu, Deborah L. Chapman et al. · Nature Genetics · 1995 · 794 citations

Life Sciences, Genetics, Molecular Genetics +14

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

Jacqueline K. White, Wojtek Auerbach, Mabel P. Duyao et al. · Nature Genetics · 1997 · 526 citations

Life Sciences, Genetics, Neuroscience +11