Are patients with rheumatoid arthritis still at an increased risk of tuberculosis and what is the role of biological treatments?

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

Joseph Keane, Sharon K. Gershon, Robert P. Wise et al. · New England Journal of Medicine · 2001 · 3.7K citations · Full text

Medicine, Immunology, Pharmacotherapy +16

Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial

Ravinder N. Maini, E. William St. Clair, Ferdinand C. Breedveld et al. · The Lancet · 1999 · 2.4K citations

Medicine, Pharmacology, Pharmacotherapy +17

Treatment of rheumatoid arthritis with tumor necrosis factor inhibitors may predispose to significant increase in tuberculosis risk: A multicenter active‐surveillance report

Juan J. Gómez‐Reino, Loreto Carmona, Vicente Rodríguez Valverde et al. · Arthritis & Rheumatism · 2003 · 1K citations

Medicine, Internal Medicine, Pharmacotherapy +15

Granulomatous Infectious Diseases Associated with Tumor Necrosis Factor Antagonists

Robert S. Wallis, Michael S. Broder, Jia Yi Karen Wong et al. · Clinical Infectious Diseases · 2004 · 978 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +10

Rates of serious infection, including site‐specific and bacterial intracellular infection, in rheumatoid arthritis patients receiving anti–tumor necrosis factor therapy: Results from the British Society for Rheumatology Biologics Register

William G Dixon, K. Watson, Mark Lunt et al. · Arthritis & Rheumatism · 2006 · 754 citations

Medicine, Infectious Diseases, Internal Medicine +15