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Sensitization of Dural Afferents Underlies Migraine-Related Behavior following Meningeal Application of Interleukin-6 (IL-6)

Jin Yan, Ohannes K. Melemedjian, Theodore J. Price, Gregory Dussor

Molecular Pain · 2012 · 137 citations · 34 references

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Abstract

Our results indicate that IL-6 enhances the excitability of dural afferents likely via ERK-mediated modulation of Nav1.7 and these responses contribute to migraine-related pain behavior in vivo. These data provide a cellular mechanism by which IL-6 in the meninges causes sensitization of dural afferents therefore contributing to the pathogenesis of migraine headache.

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