The central projection of muscle afferent fibres to the lower medulla and upper spinal cord: An anatomical study in the cat with the transganglionic transport method

TLDR

The study mapped muscle afferent projections in cats using transganglionic transport of wheat germ agglutinin‑horseradish peroxidase. The results revealed a precise musculotopic termination pattern in the external cuneate nucleus—intrinsic paw muscles medially, forearm/arm/shoulder laterally, and neck/thoracic muscles ventrolateral/dorsolateral—while fibers to the main cuneate nucleus project ventrally, and in the spinal cord to laminae I and V and the central cervical nucleus, with no topographic organization for neck muscle fibers in the ventral region.

Abstract

Abstract The projection of muscle afferent fibres to the medulla oblongata and upper spinal cord was studied in the cat by using transganglionic transport of wheat germ agglutinin‐horseradish peroxidase conjugate. The results demonstrate a precise, musculotopic termination pattern in the external cuneate nucleus; thus, fibres from the intrinsic muscles of the paw terminate medially; those from forearm, arm, and shoulder muscles terminate progressively more laterally; and those from neck and thoracic muscles terminate in the ventrolateral and dorsolateral parts, respectively. Muscle afferent fibres to the main cuneate nucleus terminate in the ventral “reticular” region of the nucleus, with a sparse projection also to the ventral part of the rostral and caudal regions, including the base of the dorsal horn. Fibres from the neck muscles terminate slightly more laterally in the ventral region than do those from the limb muscles, but otherwise, and thus contrary to the case in the external cuneate nucleus, no topographic organization was detected. In the spinal cord, projection was found to laminae I and V, and from the musculature of the back of the neck to the central cervical nucleus.