Clinical Characteristics Associated with Isolation of Small-Colony Variants of <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> from Respiratory Secretions of Patients with Cystic Fibrosis

Abstract

During a 3-month period, small-colony variant phenotypes of both Staphylococcus aureus and Pseudomonas aeruginosa were isolated from respiratory secretions of 8.2% and 9.2%, respectively, of 98 patients with cystic fibrosis, particularly those with advanced pulmonary disease and prolonged antibiotic exposure.