Hepatitis B Virus X (HBx) Induces Tumorigenicity of Hepatic Progenitor Cells in 3,5–Diethoxycarbonyl–1,4–Dihydrocollidine–Treated HBx Transgenic Mice

Abstract

HBx induces intrinsic cellular transformation promoting the expansion and tumorigenicity of HPCs in DDC-treated mice, which may be a possible origin for liver cancer induced by chronic hepatitis infection.