A C‐Linked Disaccharide Analogue of Thomsen–Friedenreich Epitope Induces a Strong Immune Response in Mice

Abstract

Anticancer vaccine: Antigen 2 made out of a tripeptide of β-D-Galp-(1→3)-CH2-α-D-GalNAc-O-Ser and conjugated with keyhole limpet hemocyanin (KLH) protein induced an early and strong immune response (IgG antibodies) in mice. Antigen 3 made out of an α-C-galactoside analogue did not induce such an immune response (see scheme). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.