Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

Mitchell S. Finkel, Carmine V. Oddis, Timothy D. Jacob et al. · Science · 1992 · 1.6K citations

Veterinary Medicine, Pharmacology, Physiology +14

Profound but Reversible Myocardial Depression in Patients with Septic Shock

Margaret M. Parker · Annals of Internal Medicine · 1984 · 1.6K citations

Medicine, Cardiology, Critical Care Cardiology +10

Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart.

Tetsuji Yokoyama, Luis Vaca, Roger D. Rossen et al. · Journal of Clinical Investigation · 1993 · 717 citations · Full text

Life Sciences, Cardiology, Physiology +13

Endotoxemia in Human Septic Shock

Robert L. Danner, Ronald J. Elin, J M Hosseini et al. · CHEST Journal · 1991 · 666 citations

Veterinary Medicine, Immunology, Physiology +16

A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.

Joseph E. Parrillo, Cynthia Burch, James H. Shelhamer et al. · Journal of Clinical Investigation · 1985 · 621 citations · Full text

Veterinary Medicine, Cardiology, Physiology +12