Neurology · 2004 · 49 citations · 6 references
MedicinePharmacologyPharmacotherapyDialysisHemodialysisRenal Replacement TherapyChronic HemodialysisDialysis PharmacotherapyDopaminergic PharmacologyRenal DiseaseRenal PharmacologyRestless Legs SyndromeDopamine Receptor AgonistsImpaired Kidney FunctionRenal DrugsRenal Failure-associated Restless Legs SyndromeRestless Legs Syndrome AssessmentRestless Legs Syndrome PathophysiologyRestless Legs Syndrome Pharmacotherapy
Restless legs syndrome (RLS) is common and severe in uremic patients.1 The restoration of normal kidney function by a successful transplant may resolve uremic RLS,1 but unfortunately this is not an option for all patients. Levodopa has been used with success,2 but it is associated with rebound and increased symptoms. Dopamine agonists are a useful alternative in severe RLS. Pramipexole has been found effective in controlled studies in idiopathic RLS,3 but, to our knowledge, it has not been used in uremic RLS. We describe an experience using pramipexole in uremic RLS in patients undergoing dialysis. One hundred seventy-two patients on hemodialysis were screened by two neurologists for RLS, using the criteria proposed by the International Restless Legs Syndrome Study Group.4 We recruited patients whose symptoms were severe enough to interfere with dialysis: They needed to be disconnected most of the time to …
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Restless legs syndrome improved by pramipexole
Jacques Montplaisir, Alain Nicolas, Régine Denesle et al. · Neurology · 1999 · 344 citations
L-Dopa Therapy of Uremic and Idiopathic Restless Legs Syndrome: A Double-Blind, Crossover Trial
Claudia Trenkwalder, Karin Stiasny, T. Pollmächer et al. · SLEEP · 1995 · 256 citations · Full text