International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · 1972 · 21 citations · 0 references
Dna DamageRadiation EffectRadiation ExposureMolecular BiologyRadiation-induced TransientsRadiation BiologyRedox BiologyOxidative StressOh-induced TransientsRadiation ChemistryNuclear MedicineDna BasesPhotochemistryBiochemistryRadical (Chemistry)Second-order Rate ConstantsDna ReplicationNatural SciencesMedicineChemical KineticsPulse-radiolysis Technique
Second-order rate constants (k′) have been determined by pulse-radiolysis technique for reactions of OH-induced transients in each of the four DNA bases with three organic nitroxyl compounds, thus: The structural formula of the nitroxyl compounds, which are known to enhance specifically the radiation-induced lethality of anoxic cells, are as follows: The reactions have been studied in 2 x 10-3 M phosphate buffer, pH 7 and the results are presented.