Concepedia

Synergistic Effect of an Endothelin Type A Receptor Antagonist, S-0139, With rtPA on the Neuroprotection After Embolic Stroke

Rui Lan Zhang, Chunling Zhang, Li Zhang, Cindi Roberts, Mei Lü, Alissa Kapke, Yisheng Cui, Mitsuyoshi Ninomiya, Toshiaki Nagafuji, Bruce Albala,

Stroke · 2008 · 43 citations · 27 references

DOIFull text

Open access

Abstract

These data suggest that S-0139 provides the neuroprotection by suppressing ischemia- and rtPA-triggered molecules that evoke thrombosis and BBB disruption.

References

27

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

Akiko Inoue, Masashi Yanagisawa, Sadao Kimura et al. · Proceedings of the National Academy of Sciences · 1989 · 2.5K citations · Full text

, , +17

'Malignant' Middle Cerebral Artery Territory Infarction

Werner Hacke · Archives of Neurology · 1996 · 1.3K citations

Protease-activated receptor 3 is a second thrombin receptor in humans

Hiroaki Ishihara, Andrew J. Connolly, Dewan Zeng et al. · Nature · 1997 · 873 citations

, , +14

Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats

Lei Wang, Zhenggang Zhang, Ying Wang et al. · Stroke · 2004 · 760 citations

Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia

Rong Zhang, Z.G Zhang, L Zhang et al. · Neuroscience · 2001 · 571 citations

, , +17