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Structure of HIV-1 protease with KNI-272, a tight-binding transition-state analog containing allophenylnorstatine

Eric T. Baldwin, Talapady N. Bhat, Sergei Gulnik, Beishan Liu, Igor A. Topol, Yoshiaki Kiso, Tsutomu Mimoto, Hiroaki Mitsuya, John W. Erickson

Structure · 1995 · 166 citations · 27 references

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27

On the size of the active site in proteases. I. Papain

Israël Schechter, Arieh Berger · Biochemical and Biophysical Research Communications · 1967 · 5.2K citations

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Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors

Patrick Y. S. Lam, Prabhakar K. Jadhav, Charles J. Eyermann et al. · Science · 1994 · 836 citations

, , +16

Bound water molecules and conformational stabilization help mediate an antigen-antibody association.

Thirumaleshwara N. Bhat, G.A. Bentley, G. Boulot et al. · Proceedings of the National Academy of Sciences · 1994 · 480 citations

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X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor.

Amy L. Swain, Maria Miller, Jeremy Green et al. · Proceedings of the National Academy of Sciences · 1990 · 275 citations

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Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere

Antonin Kröhn, Sally Redshaw, Jenny C. Ritchie et al. · Journal of Medicinal Chemistry · 1991 · 233 citations · Full text

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