MALE ANTIFERTILITY COMPOUNDS: STRUCTURE AND ACTIVITY RELATIONSHIPS OF U-5897, U-15,646 AND RELATED SUBSTANCES

Abstract

Summary. U-5897 (3-chloro-1,2-propanediol), U-15,646 (1,1′-(pentamethylenedioxy) bis [3-chloro-2-propanol]), and some related compounds were found to have antifertility activity in the male rat. Oral administration for 8 days produced temporary sterility of a functional type in the male. Structural characteristics for activity were studied.