Synthesis of Rimocidinolide Methyl Ester, the Aglycone of (+)‐Rimocidin

Abstract

An efficient, convergent route based on cyanohydrin acetonide couplings was used for the synthesis of the aglycone of rimocidin, rimocidinolide methyl ester (1). Cyanohydrin acetonides were used as β-hydroxyketone synthetic equivalents in the assembly of the polyol chain.