Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C–ι

PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity

Michihiro Matsumoto, Wataru Ogawa, Kazunori Akimoto et al. · Journal of Clinical Investigation · 2003 · 173 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +17

Activation of Protein Kinase C-ζ by Insulin and Phosphatidylinositol-3,4,5-(PO4)3 Is Defective in Muscle in Type 2 Diabetes and Impaired Glucose Tolerance

Mary Beeson, Mini P. Sajan, M. Dizon et al. · Diabetes · 2003 · 162 citations · Full text

Life Sciences, Endocrinology, Molecular Biology +16

Muscle-specific knockout of PKC-λ impairs glucose transport and induces metabolic and diabetic syndromes

Robert V. Farese, Mini P. Sajan, Hong Yang et al. · Journal of Clinical Investigation · 2007 · 162 citations · Full text

Medicine, Endocrinology, Physiology +17

Insulin-Stimulated Protein Kinase C λ/ζ Activity Is Reduced in Skeletal Muscle of Humans With Obesity and Type 2 Diabetes

Young‐Bum Kim, Ko Kotani, Theodore P. Ciaraldi et al. · Diabetes · 2003 · 157 citations · Full text

Life Sciences, Endocrinology, Physiology +13

A Novel Small-Molecule Inhibitor of Protein Kinase Cι Blocks Transformed Growth of Non–Small-Cell Lung Cancer Cells

Melody Stallings‐Mann, Lee Jamieson, Roderick P. Regala et al. · Cancer Research · 2006 · 152 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13