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Gene Transfer of Human <i>Apoe</i> Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

Eloïse Hudry, Jonathan Dashkoff, Alysson D. Roe, Shuko Takeda, Robert M. Koffie, Tadafumi Hashimoto, Maria Scheel, Tara L. Spires‐Jones, Michal Arbel‐Ornath, Rebecca A. Betensky,

Science Translational Medicine · 2013 · 182 citations · 45 references

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Abstract

Introduction of different APOE isoforms modulates Aβ peptide aggregation and neurotoxicity after amyloid deposition in mouse brain.

References

45

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Karen Hsiao, Paul F. Chapman, Steven P. Nilsen et al. · Science · 1996 · 4.2K citations

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

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Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Robert D. Bell, Ethan A. Winkler, Itender Singh et al. · Nature · 2012 · 1.3K citations · Full text

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