Concepedia

Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient

David J. Adams, M Wahl, James L. Flowers, Banalata Sen, Michael Colvin, Mark W. Dewhirst, Govindarajan Manikumar, Mansukh C. Wani

Cancer Chemotherapy and Pharmacology · 2005 · 63 citations · 32 references

DOI

Concepts

References

32

Acid pH in tumors and its potential for therapeutic exploitation.

Ian F. Tannock, Daniela Rotin · PubMed · 1989 · 1.6K citations

, , +16

Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer.

L.E. Gerweck, Koushik Seetharaman · PubMed · 1996 · 1.1K citations

, , +15

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

Peter Vaupel, Karlheinz Schlenger, Claudia Knoop et al. · PubMed · 1991 · 957 citations

, , +15

DNA Topoisomerase I—Targeted Chemotherapy of Human Colon Cancer in Xenografts

Beppino C. Giovanella, John S. Stehlin, Monroe E. Wall et al. · Science · 1989 · 647 citations

, , +15

Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma

Reinhard Bos, Petra van der Groep, Astrid E. Greijer et al. · Cancer · 2003 · 499 citations · Full text

, , +14