Total Synthesis of (+)‐Fawcettidine

Abstract

Alkaloids alchemy: A synthesis of the Lycopodium alkaloid (+)-fawcettidine (see structure) has been developed which requires 16 steps from (R)-(+)-pulegone as the chiral starting material. Key steps include a platinum(II)-catalyzed annulation reaction of a functionalized enamide and a one-pot Ramberg–Bäcklund process.