Concepedia

Overexpression of Bcl-2 by activated human hepatic stellate cells: resistance to apoptosis as a mechanism of progressive hepatic fibrogenesis in humans

Erica Novo, Fabio Marra, E. Zamara, L. Valfrè di Bonzo, Luigia Monitillo, Stefania Cannito, Ilaria Petrai, Antonio Mazzocca, Andrea Bonacchi, Robert S. Franco,

Gut · 2006 · 162 citations · 34 references

DOIFull text

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Abstract

Human activated HSC/MFs are resistant to most proapoptotic stimuli due to Bcl-2 overexpression and this feature may play a key role in the progression of fibrosis in chronic liver diseases.

References

34

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

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Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.

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Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

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A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis☆

Stuart J. Forbes, Francesco Paolo Russo, Virginia Rey et al. · Gastroenterology · 2004 · 430 citations

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