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Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation

Ryota Terada, Sonisha Warren, Jonathan T. Lu, Kenneth R. Chien, Andy Wessels, Hideko Kasahara

Cardiovascular Research · 2011 · 72 citations · 52 references

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Abstract

Nkx2-5 is necessary for survival after the mid-embryonic stage for cardiac function and formation by regulating the expression of its downstream target genes.

References

52

Efficient Recombination in Diverse Tissues by a Tamoxifen-Inducible Form of Cre: A Tool for Temporally Regulated Gene Activation/Inactivation in the Mouse

Shigemi Hayashi, Andrew P. McMahon · Developmental Biology · 2002 · 1.4K citations

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Congenital Heart Disease Caused by Mutations in the Transcription Factor <i>NKX2-5</i>

Jean‐Jacques Schott, D. Woodrow Benson, Craig T. Basson et al. · Science · 1998 · 1.3K citations

Fate of the mammalian cardiac neural crest

Xiaobing Jiang, David H. Rowitch, Philippe Soriano et al. · Development · 2000 · 1.1K citations

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.

Ian Lyons, Linda M. Parsons, Lynne Hartley et al. · Genes & Development · 1995 · 1.1K citations · Full text

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A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease

Benoit G. Bruneau, Georges Nemer, Joachim P. Schmitt et al. · Cell · 2001 · 1.1K citations · Full text

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